Journal Jam 18 The Evidence for TXA – Should Tranexamic Acid Be Routine Therapy in the Bleeding Patient?
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The Pitfalls of Subgroup Analysis in Medical Trials
This chapter explores the issue of subgroup analysis in medical trials, emphasizing the need to view subgroups as hypothesis-generating rather than conclusive evidence. It discusses a study by Wallach et al. that found no confirmation of original subgroups showing potential benefit in follow-up trials, highlighting the importance of considering overall trial results.
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