Modeling the Nervous System with Organoids

Research conducted by Dr. Ziwan Guo focuses on creating human nervous system models using induced pluripotent stem cells (iPSCs) to study neurodevelopmental and neurodegenerative disorders. His lab aims to develop cerebral organoids that closely mimic real human brain tissues, allowing for a better understanding of diseases like autism and Alzheimer's. The work emphasizes the importance of authenticity in organoid models, as they strive to replicate cellular interactions and signaling pathways observed in actual brain environments. This approach not only advances basic science but also is crucial for identifying potential therapeutic strategies for complex neurological disorders.