Innovative Approaches to Organoid Development

This chapter examines the urgent need for faster organoid development methods, proposing a two-week differentiation process in contrast to traditional one-year timelines. It highlights a pivotal study that investigates how engineered substrates can mimic blastocyst geometry to enhance the longevity and potency of naive pluripotent stem cells. Additionally, the chapter explores the influence of substrate mechanics on cell behavior, particularly in the maturation of somatosensory neurons and their excitability.