Innovations in Celiac Disease Organoid Modeling

This chapter explores the development of an in vitro model for celiac disease using air-liquid interface duodenal organoids that retain tissue structure and immune components. It highlights the role of interleukin-7 as a potential biomarker and discusses the importance of immune niches for accurately mimicking the disease. The chapter also covers advancements in organoid technology addressing the challenges of studying autoimmune responses and drug toxicity.