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Dr. Andy Galpin: How to Build Strength, Muscle Size & Endurance
Effect of energy intake and expenditure on muscle growth
AI Key Takeaways
- Total energy intake is important for maintaining an anabolic state.
- Extra energy expenditure can put you in a negative energy state.
- Consistent, high volume exercise is necessary for desired outcomes.
- The signaling pathway called mTOR is associated with muscle growth.
- The molecule AMPK is associated with mitochondria and endurance.
- Activation of AMPK inhibits mTOR through TSC2.
- Hickman's findings had practical and mechanistic implications.
@stephenpribut
Ep. 280: Imre Lakatos on Scientific Progress (Part One)
The Epistemological Component of Scientific Knowledge
AI Key Takeaways
- The issue is not only limited to modern times but has an epistemological aspect to it.
- There has been a separation of knowledge from what constitutes scientific knowledge over time.
- Justification ism claims that scientific knowledge is based on empirical senses, which is not accurate.
- Probabilism suggests that some theories are more likely to be true based on probability.
@stephenpribut
TWiN 40: Dopamine organizes behavior's syllables
The Mystery of Dopamine Release and its Effect on Behavior
AI Key Takeaways
- Dopamine's involvement in making behavioral modules more stochastic is a topic to be discussed later.
- Dopamine is unique in that we don't fully understand how it gets released at the molecular level.
- Dopamine is not released through canonical synaptic vesicles.
- The localization and spatial domain of dopamine release is still a mystery.
- Dopamine release occurs through pharocosins, which are not true synapses and through volume transmission.
- Dopamine is quickly taken back up by the dopamine transporter, but when not taken up quickly, it can alter behavior such as in the case of cocaine or ritalin use.
@stephenpribut
#252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D.
The Effect of Cardiovascular Fitness on Alzheimer's Risk: A Study Comparison
AI Key Takeaways
- Cardiovascular fitness is associated with robust reduction in Alzheimer's risk, up to 9 times more likely for the most fit women
- Questionnaire studies can show conflicting results with regards to the relationship between physical activity and dementia risk, highlighting the importance of considering study design
@stephenpribut
#252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D.
Exercise drives production Brain Derived Neurotrophic Factor (BDNF)
AI Key Takeaways
- Exercise increases brain drive neurotrophic factor (BDNF) in many different parts of the body including the brain, heart, and muscle.
- The sheer force of blood flow during exercise can signal an increase in BDNF.
- BDNF plays a role in repairing damaged muscle and is important for long-term potentiation and neuroplasticity.
@stephenpribut
#252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D.
Diabetes is not inevitable but it accelerates Alzheimers & Heart Disease.
AI Key Takeaways
- Type 2 diabetes is not inevitable for humans, but atherosclerosis and cancer are.
- Delaying the onset and detecting cancer early can reduce the risk and increase treatment success.
- Humans can die with atherosclerosis, but not from it.
@stephenpribut
#252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D.
The Role of Omega-3 in Blood Brain Barrier Integrity and Alzheimer's Disease Prevention
AI Key Takeaways
- The speaker joined the Fatty Acid Research Institute to look at the role of omega-3 with blood brain barrier integrity and biomarkers in people with small vessel disease
- Research in this area is important due to its implications for Alzheimer's disease
- Important lifestyle interventions for blood brain barrier include fixing type 2 diabetes and increasing omega-3 intake by eating more fatty fish or supplementing
- Low omega-3 intake from fish is identified as one of the top six preventable causes of an issue in a 2012 Harvard study
@stephenpribut
#252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D.
The Challenges of Targeting Alzheimer's Disease
AI Key Takeaways
- The three major pathologies of Alzheimer's disease are amyloid plaques in the brain, tautangles, and glucose hypometabolism.
- Researchers have largely focused on the anti-amyloid hypothesis in Alzheimer's disease treatment, but many trials have failed and it's unclear if targeting the symptom is enough.
- New studies by Barisov-Slovovic at USC and Dr. Axel Montane at the University of Edinburgh suggest alternative approaches to Alzheimer's disease treatment.
@stephenpribut
#354 – Jeremi Suri: American Civil War
The Importance of Being Iconoclastic
AI Key Takeaways
- Being an iconoclast is about loving ideas but never being comfortable with consensus.
- Consensus is overstated and a pluralistic society is better.
- Institutions should encourage different modes of thought and work through disagreement.
@stephenpribut
532: The Meat Part of Multitasking
The Decline of Web Reading and the Need for Better Reading Apps
AI Key Takeaways
- The speaker used to make a service primarily about reading things later but hasn't used it in a long time
- The web is a dumpster fire with few articles worth saving and reading
- Apple News is a bad experience with frequent ads
- The speaker started paying for a subscription to a site to avoid rationing how often they clicked on its links
@stephenpribut
#239 ‒ The science of strength, muscle, and training for longevity | Andy Galpin, Ph.D. (PART I)
How to Structure Strength Training
AI Key Takeaways
- Doing different body parts each day will help to keep the body active and recovering.
- Missing one day per month will not have a big impact on the body's ability to recover.
- Splitting the body into different parts will help to keep the body active and recover.
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