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Dr. Peter Attia: Supplements for Longevity & Their Efficacy

Huberman Lab

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Impact of Rapamycin on Aging and Life Extension

Rapamycin and its analogs, such as everolimus, significantly slow down aging by inhibiting the mTOR pathway, leading to reduced cellular growth and maturation rates. This process enhances autophagy and suppresses senescent cells, making it a compelling intervention for life extension. The strength of rapamycin's effects is backed by rigorous experimental data across a variety of organisms, including mammals, fruit flies, worms, and yeast. Notably, rapamycin is one of only two interventions, alongside caloric restriction, that has demonstrated uniform life extension across these diverse eukaryotic species, highlighting its unique role in the aging research landscape.

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