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Everything you need to know about metabolic health | Metabolic Health Masterclass

The Proof with Simon Hill

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Fat and Fructose: A Catalyst for Uric Acid Surge

Fructose significantly raises intracellular uric acid levels, which are closely associated with fatty liver conditions. The presence of uric acid serves as a marker for liver fat content, particularly noted in hibernating animals. While saturated fats also contribute to elevated uric acid levels, the combination of fructose and saturated fats exacerbates this effect. Ketosis and increased adipose fat can create a localized low-oxygen environment that further stimulates uric acid production. High-fat diets correlate with increased uric acid, with studies indicating that saturated fats may have a more pronounced effect than polyunsaturated fats. Elevated uric acid levels induce oxidative stress in mitochondria, leading to increased fat synthesis and hindered fat breakdown.

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