Mitochondrial dysfunction lies at the core of the problem causing a lack of energy conversion and output in the body. This dysfunction prompts cells to store energy as fat rather than utilizing it properly. The inefficiency in mitochondria leads to the body resorting to storing substrates as toxic fats, which triggers insulin resistance. Insulin resistance occurs when cells block glucose uptake due to dysfunctional mitochondria, consequently hindering insulin signaling and glucose entry. Therefore, addressing mitochondrial function is key to enhancing energy utilization in cells and combatting insulin resistance.

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