The Impact of Movement on mitochondria and AMP accumulation

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Movement increases mitochondria production and triggers the release of a molecule called AMP, which activates a protein called AMP kinase. AMP kinase's role is to attach phosphate molecules to other proteins, activating a protein called PGC-one. PGC-one, short for peroxisome proliferator-activated receptor gamma coactivator 1, is involved in promoting mitochondrial biogenesis. So, movement not only burns calories but also stimulates the production of more mitochondria.

In Episode #222, I’m joined by Drew Harrisberg and Kieron Rooney, PhD to discuss how the biochemistry of exercise can impact your health. We cover a wide range of topics, including mitochondria efficiency, metabolic flexibility, and fat adaptation. Dr Rooney also offers training advice, and his thoughts on a ketogenic diet.

Evidence continuously shows us that the multitude of factors contributing to health and longevity are incredibly complex. Today, Kieran Rooney, PhD sits down with Drew Harrisberg and me to break down the biochemistry behind exercise, exploring both the theory and practical applications of improving your fitness.

Specifically, we cover:

Intro (0:00)
Rodent Studies on Sucrose (5:40)
Biochemistry of Exercise (22:28)
Creatine Supplementation for Athletes (37:19)
Do you need meat for creatine? (42:40)
How Our Bodies Produce ATP (44:41)
Defining Mitochondria (58:43)
Increasing Efficiency (1:03:56)
Omega 6s: Essential or Problematic? (1:06:00)
Metabolic Flexibility (1:15:20)
Make more Mitochondria (1:18:08)
Mitochondria & Longevity (1:29:00)
Lactate Levels (1:35:14)
Best Training Advice (1:50:16)
HIIT vs Endurance (2:01:10)
Can Keto Work Long-Term? (2:12:42)
Outro (2:45:15)

To connect with Drew Harrisberg, you can find him on Instagram and visit his website, Drew’s Daily Dose. Kieron Rooney, PhD is active on Twitter, and you can learn more about him and his work here.

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Enjoy, friends.

Simon

Want to support the show?

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Simon Hill, Msc, Bsc (Hons)

Creator of Theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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