The lack of insulin in the past led to starvation diets for type one diabetics, resulting in death within a year. However, the synthesis of peptides and their health benefits led to increased lifespans. The ability to synthesize peptides through recombinant DNA technology in the 1978s made them more accessible. Peptides can now be easily synthesized on machines, making them inexpensive. This ease of synthesis has led to some individuals self-producing and administering peptides at home, despite it being off-label. Peptides have been extensively studied due to their low cost, low toxicity, and ease of synthesis, with thousands of human studies conducted.

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