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Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Huberman Lab

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Exploring Sleep Quality: The Role of REM, Pinealine, and Glycine

Lack of rapid eye movement (REM) sleep has significant negative effects on neuroplasticity, emotional processing, and overall mental health, exacerbating numerous mental health issues and increasing suicide rates. Pinealine is gaining attention for its ability to potentially enhance sleep quality and REM sleep, though it should not be seen as a miracle solution. While some FDA-approved sleep medications like Quivivic focus on suppressing wakefulness to increase REM sleep, personal experiences with these drugs can vary widely, with many reporting ineffective results. In contrast, pinealine has shown remarkable effects, even contributing to improved sleep quality on nights when it is not taken, suggesting a regenerative role in melatonin production. Additionally, combining pinealine with glycine may further enhance sleep quality. Glycine acts as an inhibitory neurotransmitter, helping to calm the nervous system and ease the transition to sleep, potentially benefiting liver function as well by supporting detoxification processes. As such, glycine can play an important role in overall health and sleep improvement, emphasizing the need for a holistic approach to managing sleep issues through dietary, lifestyle, and mental health strategies.

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