Low-Dose Nicotine for Cognitive Function and Longevity

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Low doses of pharmaceutically extracted nicotine, distinct from tobacco, can positively impact cognitive function and longevity by raising PGC1 alpha levels, potentially reducing the risk of Alzheimer's and Parkinson's diseases. This low dose shows promise as a potent nootropic and exercise mimetic. Pharmaceutical nicotine, when taken in the range of one to five milligrams for individuals over 40, may have beneficial effects on cognitive function and nicotinic acid receptors due to its impact on PGC1 alpha levels.

In this episode of The Human Upgrade, Dr. John Gildea and David Roberts from BrocElite join to discuss the powerful benefits of sulforaphane and NRF2 activation. You'll hear about the science behind sulforaphane, a potent compound in broccoli, and how it can boost your health by protecting your cells and enhancing detoxification.

Learn why eating broccoli and broccoli sprouts can be a game-changer for your diet and get practical tips on how to incorporate them into your meals. The discussion highlights the role of sulforaphane in supporting gut health and improving resilience to toxins.

Dr. Gildea and David Roberts explain the importance of NRF2 activation in promoting longevity and better performance. You'll understand how these mechanisms work to keep your body functioning optimally and how you can leverage them for better health. Tune in to gain valuable insights and actionable advice on enhancing your health with sulforaphane and NRF2 activation!

Timestamp Highlights:

(00:00:00) Introduction: Benefits of sulforaphane and NRF2 activation.

(00:01:04) Are Bodybuilders the Edgiest Biohackers?

(00:02:10) Benefits of Broccoli and Sulforaphane

(00:04:23) Isothiocyanates and Thyroid Function

(00:10:57) Longevity and Performance Impacts of NRF2

(00:18:20) Resilience Against Toxins

(00:24:57) Sulforaphane and Autism

(00:31:08) Anti-Inflammatory Effects of Sulforaphane

(00:40:52) Gut Health and Microbiome

(00:45:58) Autophagy and Cellular Health

(00:55:57) Dosage and Safety

(01:02:00) Closing Thoughts

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