Switching from processed foods to real, unprocessed, nutrient-rich foods for a period of one to two months can lead to significant changes in our microbiome, neurocircuitry, and reward circuitry. This transition allows us to find pleasure and joy in natural, fresh foods, breaking the dopamine loop associated with processed foods. While it may be challenging, understanding the biology behind our food choices can give us the strength to transition to a diet that brings much more satisfaction.