Prioritize Liver Health Before Treatment

In managing patients with hemochromatosis or elevated BMI and non-alcoholic steatohepatitis (NASH), careful consideration of liver function is crucial before prescribing methotrexate. Involving hepatology and nutrition early in the treatment process is recommended to accurately assess liver safety and toxicity. It is imperative that liver transaminases are within normal limits prior to initiating treatment with methotrexate to minimize the risks associated with potential liver toxicity.