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Impact of Accumulated Lesser Significant Genetic Mutations
Genetic mutations, although individually less significant, can have a substantial impact when accumulated together on a single gene. These holistic genes, present in a majority of the population, can collectively contribute to significant health effects. For example, the DHCR7 mutation, responsible for converting cholesterol into vitamin D, is linked to various health conditions such as early onset dementia, Alzheimer's disease, and diabetes. Even a single mutation can have a noticeable effect on health outcomes, highlighting the importance of considering accumulated lesser significant genetic mutations in studies and health management.