Adapt to the Heart's Limits

Patients with fixed stroke volume rely heavily on elevated heart rates to sustain cardiac output. Administration of therapies that cause vasodilation may lead to poor tolerance in these individuals, necessitating caution and often requiring cessation of medications like ACE inhibitors, ARBs, and beta blockers if adverse symptoms such as orthostasis or worsening kidney function arise. Unlike standard heart failure patients, those with conditions like amyloidosis require a distinct approach to medication management; the discontinuation of beta blockers can significantly improve their well-being, showcasing the importance of tailoring treatment to individual cardiac function nuances.