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Mitochondrial Health and Urolithin A with Dr. Anurag Singh | The Metabolic Link Ep. 41

The Metabolic Link

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Exploring the Role of Mitophagy and Experimental Measurement Methods

Innovative approaches are crucial in developing compounds, such as incorporating a measurement system due to the impact of food on drug metabolism and individual pharmacokinetics. Mitochondria play a vital role in energy production, aging results in unhealthy mitochondria accumulating and slowing down the recycling mechanisms, termed as mitophagy. Ehrlichineo Mitopure induces mitophagy by tagging and clearing out faulty mitochondria, promoting the generation of new healthy mitochondria, known as biogenesis. Experimental measurement of mitophagy and mitochondrial biogenesis involves using markers such as PGC1 alpha in tools like flow cytometry, western blot, and non-invasive methods like magnetic spectroscopy with MRI to assess mitochondrial health through ATP replenishment rates and VO2 levels.

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