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Nutrition to Support Brain Health & Offset Brain Injuries

Perform with Dr. Andy Galpin

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Role of Branched Chain Amino Acids in TBI Symptoms

Branched Chain Amino Acids (BCAAs) consist of isoleucine, leucine, and valine, with leucine primarily driving muscle protein synthesis. However, they play a distinct role in brain health, particularly concerning Traumatic Brain Injury (TBI) symptoms. Research indicates that a greater suppression of BCAAs in the brain correlates with more severe TBI symptoms. BCAAs function as nitrogen donors, facilitating the production of neurotransmitters like glutamate and GABA, which are critical in TBI pathology. They also influence the transport of tryptophan and tyrosine across the blood-brain barrier. Elevated BCAA levels can hinder the uptake of these amino acids, potentially affecting serotonin production and leading to sleep disturbances commonly associated with TBI. Despite concerns surrounding sleep, evidence suggests BCAAs may improve sleep quality, particularly in veterans suffering from chronic TBI, with studies indicating a positive effect on insomnia and latency issues. Overall, the strength of existing evidence supports the beneficial role of BCAAs in addressing TBI-related symptoms, particularly concerning sleep disruptions.

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