AI-powered
podcast player
Listen to all your favourite podcasts with AI-powered features
3min snip
The Scientific Journey Behind Ozempic (with Lotte Bjerre Knudsen, Novo Nordisk's Chief Scientific Advisor)
ACQ2 by Acquired
Exploring the Science of Weight Loss Medication Development
Caloric restriction leads to weight loss, but the body adjusts energy expenditure to combat this loss, emphasizing the need for exercise to maintain metabolism. Developing semaglutide with a longer half-life than liraglutide was aimed at enhancing weight loss effectiveness by increasing stickiness to albumin in the body. Through extensive chemistry work, semaglutide was engineered to bind harder to albumin, leading to a longer half-life compared to liraglutide. The increased stickiness of semaglutide potentially allows it to target important brain areas for enhanced weight loss.
00:00
Transcript
Episode notes
Get the Snipd
podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered
Discover
highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any
moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share
& Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered
podcast player
Listen to all your favourite podcasts with AI-powered features
Discover
highlights
Listen to the best highlights from the podcasts you love and dive into the full episode