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ACQ2 by Acquired
The Scientific Journey Behind Ozempic (with Lotte Bjerre Knudsen, Novo Nordisk's Chief Scientific Advisor)
Mar 6, 2024
Dive into the fascinating world of Ozempic's scientific journey with Novo Nordisk's chief scientific advisor. Learn about the science behind weight loss on Ozempic, the 90s belief in a groundbreaking drug, and weight loss as a primary goal from the start. Explore the challenges and innovations in developing pharmaceutical technologies and the mechanisms of GOP one agents for diabetes and weight loss.
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Quick takeaways
- GLP-1 agonists like Semaglutide work by increasing insulin levels and lowering glucagon levels for blood glucose control.
- Innovative chemical engineering efforts led to the development of Semaglutide with an extended half-life and increased weight loss outcomes.
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The Science behind GLP1 Agonists for Weight Loss and Diabetes Treatment
GLP1 agonists like Lira Glutide and Semaglutide work by increasing insulin levels and lowering glucagon levels, thereby reducing blood glucose. They also slow down food absorption in the intestine, helping to stabilize blood glucose levels after eating. Additionally, these medications help individuals consume fewer calories, leading to weight loss. The availability of Semaglutide once weekly injection provided a longer-lasting effect with doubled weight loss outcomes by reducing energy intake compared to Lira Glutide.
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