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#179 – Randy Nesse on why evolution left us so vulnerable to depression and anxiety

80,000 Hours Podcast

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Uncovering the Mystery of Severe Depression

Severe depression is a common phenomenon that remains a mystery in mood research. The concept of kindling, derived from epilepsy research, suggests that inducing seizures in animals can make them more prone to future seizures with less stimulation. Similarly, in depression, unresolved ordinary low moods may lead to dysregulation, making individuals unaware of opportunities or trapped in repeated negative experiences.

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