The Pros and Cons of GLP-1 Drugs for Weight Loss

GLP-1 drugs mimic the effects of the GLP-1 hormone, providing significant weight loss benefits by prolonging feelings of fullness and slowing gastric emptying, resulting in reported weight losses of 30-40%. These drugs have become extremely popular, driving substantial profits for major pharmaceutical companies. Alongside the weight loss, GLP-1 drugs are associated with cardiovascular benefits and improved kidney function. However, the drawbacks include high costs prohibiting widespread access, a range of side effects such as bloating, diarrhea, and in some cases, severe reactions, leading to about 15-20% of users not tolerating the treatment. Additionally, long-term sustainability is an issue as many patients regain weight after discontinuation, raising concerns about the necessity for lifelong medication. This creates a dilemma for public health, with high costs potentially leading to increased insurance premiums. Overall, while these drugs present remarkable short-term benefits, their long-term efficacy and accessibility pose significant challenges.