Understand Fat: Hormones as Key Indicators

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Different races exhibit varying body mass index (BMI) characteristics, with Southeast Asians generally having lower BMIs and higher abdominal fat accumulation, posing risks that necessitate refined measures beyond BMI. Waist circumference should be adjusted for height to derive better health insights. Key hormones like leptin and adiponectin play crucial roles in understanding obesity and its implications. Leptin is linked with overall fat levels while adiponectin is associated with intra-abdominal fat; higher intra-abdominal fat leads to lower adiponectin levels, increasing risks for diabetes, fatty liver, and cardiovascular diseases. These hormones can be measured through standard blood tests available in most laboratories.

Episode #329. Boost metabolic health and prevent disease with expert insights from an all-star lineup of scientists. Learn key strategies for improving metabolic health, including metabolic flexibility, muscle health, and the critical roles of diet and exercise in preventing type 2 diabetes and fatty liver disease.

In this episode, you’ll hear from a distinguished panel of specialists including applied exercise physiologist Inigo San Millan, PhD; skeletal muscle expert Don Layman, PhD; type 2 diabetes authority Roy Taylor, PhD; dietitian and researcher Andrea Glenn, PhD, RD; nutrition scientist Alan Flanagan, PhD; nutrition scientist and endocrinologist Christos Mantzoros MD, DSc, PhD; and physician and researcher Richard Johnson, MD.

Specifically, we discuss:

Intro (00:00)
What is Metabolic Health (01:35)
Metabolic Health, Mitochondria, Defining 'Metabolise', Metabolic Flexibility (07:02)
The Importance of Skeletal Muscle for Metabolic Health (20:03)
Exercise for metabolic health ****Zone 2 (28:36)
Twin Cycle Hypothesis (56:45)
Understanding the Personal Fat Threshold (01:08:15)
Summary of the DiRECT Trial: Examining the Twin Cycle Hypothesis with Roy Taylor (01:17:08)
Are DASH, Nordic, Mediterranean, and Portfolio diets good for preventing and managing diabetes? (01:36:46)
Understanding Non-Alcoholic Fatty Liver Disease and Its Development (01:42:39)
The Science of Hepatic Fat Oxidation (01:49:37)
Consequences and Effects of Fatty Liver Disease (01:55:14)
Linking Non-Alcoholic Fatty Liver Disease with Type 2 Diabetes (02:00:42)
Combination of Fructose and Saturated fat on Metabolic Health (02:13:21)
Type of fat and its effect on Metabolic Health (02:17:35)
What cause Metabolic Health: fat or fructose (02:24:01)
New Fat Storage Mechanisms - Personal Fat Threshold (02:27:50)
Modern Techniques for Accurate Body Fat Measurement (02:31:52)
Health metabolic biomarkers (02:36:51)
Ectopic fat (02:38:19)
Fat storage and metabolic health (02:39:10)
Evolutionary Insights into Human Fat Storage (02:42:02)
Fatty Liver Disease (02:45:46)
Outro (2:57:46)

Connect with today’s guests and listen to their previous episodes at the links above.

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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