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Everything you Need to Know About Creatine with Dr Darren Candow
The Neuro Experience
Differential creatine storage and production in muscles and the brain
Creatine is primarily stored in muscles, where it is actively absorbed, while the brain can produce its own creatine supply. This difference in storage and production may explain why the brain responds differently to creatine supplementation or dietary creatine. The liver is the primary site of creatine production, which is then transported to the muscles and can be taken up by the brain, albeit through the blood brain barrier and specific transporters. Additionally, the brain naturally produces creatine to maintain ATP levels and may increase creatine production in times of metabolic stress.
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