Fat and Fructose: A Catalyst for Uric Acid Surge

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Fructose significantly raises intracellular uric acid levels, which are closely associated with fatty liver conditions. The presence of uric acid serves as a marker for liver fat content, particularly noted in hibernating animals. While saturated fats also contribute to elevated uric acid levels, the combination of fructose and saturated fats exacerbates this effect. Ketosis and increased adipose fat can create a localized low-oxygen environment that further stimulates uric acid production. High-fat diets correlate with increased uric acid, with studies indicating that saturated fats may have a more pronounced effect than polyunsaturated fats. Elevated uric acid levels induce oxidative stress in mitochondria, leading to increased fat synthesis and hindered fat breakdown.

Episode #329. Boost metabolic health and prevent disease with expert insights from an all-star lineup of scientists. Learn key strategies for improving metabolic health, including metabolic flexibility, muscle health, and the critical roles of diet and exercise in preventing type 2 diabetes and fatty liver disease.

In this episode, you’ll hear from a distinguished panel of specialists including applied exercise physiologist Inigo San Millan, PhD; skeletal muscle expert Don Layman, PhD; type 2 diabetes authority Roy Taylor, PhD; dietitian and researcher Andrea Glenn, PhD, RD; nutrition scientist Alan Flanagan, PhD; nutrition scientist and endocrinologist Christos Mantzoros MD, DSc, PhD; and physician and researcher Richard Johnson, MD.

Specifically, we discuss:

Intro (00:00)
What is Metabolic Health (01:35)
Metabolic Health, Mitochondria, Defining 'Metabolise', Metabolic Flexibility (07:02)
The Importance of Skeletal Muscle for Metabolic Health (20:03)
Exercise for metabolic health ****Zone 2 (28:36)
Twin Cycle Hypothesis (56:45)
Understanding the Personal Fat Threshold (01:08:15)
Summary of the DiRECT Trial: Examining the Twin Cycle Hypothesis with Roy Taylor (01:17:08)
Are DASH, Nordic, Mediterranean, and Portfolio diets good for preventing and managing diabetes? (01:36:46)
Understanding Non-Alcoholic Fatty Liver Disease and Its Development (01:42:39)
The Science of Hepatic Fat Oxidation (01:49:37)
Consequences and Effects of Fatty Liver Disease (01:55:14)
Linking Non-Alcoholic Fatty Liver Disease with Type 2 Diabetes (02:00:42)
Combination of Fructose and Saturated fat on Metabolic Health (02:13:21)
Type of fat and its effect on Metabolic Health (02:17:35)
What cause Metabolic Health: fat or fructose (02:24:01)
New Fat Storage Mechanisms - Personal Fat Threshold (02:27:50)
Modern Techniques for Accurate Body Fat Measurement (02:31:52)
Health metabolic biomarkers (02:36:51)
Ectopic fat (02:38:19)
Fat storage and metabolic health (02:39:10)
Evolutionary Insights into Human Fat Storage (02:42:02)
Fatty Liver Disease (02:45:46)
Outro (2:57:46)

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Simon Hill, MSc, BSc (Hons)

Creator of theproof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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