The immune system develops long-term memory during early childhood as it encounters various stimuli, including foods and pathogens. During infancy, when children explore the world by putting objects in their mouths, their immune systems learn to differentiate between benign and harmful substances, establishing a foundational tolerance to foods. This critical exposure enhances their immunity, and the memories formed can lead to long-term tolerance, even into adolescence. The oral exploration serves not only as a nutritional necessity but also plays a significant role in the evolutionary adaptation of the immune response, suggesting that this behavior is a natural mechanism for strengthening the immune system.

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