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Everything you need to know about metabolic health | Metabolic Health Masterclass

The Proof with Simon Hill

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The Connection Between Fructose, Saturated Fat, and Liver Health

Fructose and saturated fat interact in a way that exacerbates liver fat deposition through the generation of intracellular uric acid. Elevated uric acid levels have been linked to fatty liver conditions, as demonstrated by various studies involving hibernating animals. While fructose significantly increases uric acid, saturated fat contributes to its rise, especially in combination with fructose, indicating a synergistic effect. Saturated fat may also promote uric acid production through the induction of localized hypoxic conditions in adipose tissue, which stimulates uric acid synthesis. Additionally, high-fat diets are associated with increased uric acid levels, although specific comparisons between saturated fat and polyunsaturated fat regarding their effects on uric acid require further investigation. The elevation of uric acid leads to oxidative stress in the mitochondria, disrupting energy metabolism by promoting fat synthesis and inhibiting fat degradation. Overall, both the consumption of fructose and saturated fat plays a critical role in increasing uric acid levels and consequently influencing liver health negatively.

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