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Insights on Creatine and Brain Health
The brain creates its own creatine, but it's different from muscle in its resistance to taking in creatine from the bloodstream or supplementation. Crossing the blood-brain barrier to overcome the brain's natural creatine production may require longer-term or higher-dosage supplementation. Research suggests that it takes about 20 grams for a short period or about four grams or more for several months for creatine to accumulate in the brain. Studies show benefits of creatine supplementation in populations with compromised brain creatine such as concussion, depression, anxiety, and neuropathological diseases.