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PEA: Perspectives from a Pharmaconutritionist with Dr. Adrian Lopresti and Dr. Paul Clayton
FX Medicine Podcast Central
The Modulation of Body's Response System
Activation of G protein coupled receptors 55 and 119 along with indirect activation of cannabinoid receptors CB1 and CB2 leads to the entourage effect. This effect involves inhibiting the degradation of anandamide by synthesizing PEI and inhibiting FAAH enzyme, which results in reduced mast cell degranulation. Additionally, the activation at the vanilloid one receptor contributes to anti-allergic and analgesic effects. Overall, these mechanisms dampen the body's initial response to tissue stress, injury, and damage, forming a protective and modulatory system.
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