PEA: Perspectives from a Pharmaconutritionist with Dr. Adrian Lopresti and Dr. Paul Clayton
Feb 12, 2024
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Dr. Adrian Lopresti and Dr. Paul Clayton discuss the role of PEA in various conditions, chronic inflammation, neuroinflammatory diseases, and the effective management of acute and chronic conditions. They explore PEA's therapeutic potential, optimal dosages, safety, and comparisons with CBD. The podcast also covers nutrient incorporation from food sources vs. supplements, polyphenols, pre-biotic fibers for inflammation and pain management, and enthusiasm for pharmaconutrition research.
PEA serves as a versatile supplement with anti-inflammatory and neuroprotective effects, offering a wide therapeutic index.
Pharmaconutrition addresses metabolic errors in chronic diseases through nutritional balance, promoting repair and regeneration.
Deep dives
Importance of Pharmaconutrition in Healthcare
Pharmaconutrition, a novel approach in healthcare, focuses on using the known pharmacological functions of different foods to address multiple metabolic errors causing chronic degenerative diseases. Unlike traditional targeted medicine, pharmaconutrition takes a comprehensive Bernardian approach, aiming to nullify metabolic errors to promote repair and regeneration in the body. By balancing nutritional imbalances, pharmaconutrition shows promise in slowing disease progression and achieving remission for many patients.
Potential Benefits and Safety of PEA
Palmitoylethanolamide (PEA) is highlighted for its role in dampening or modulating the body's stress responses to tissue damage and inflammation. PEA functions as an autocoid, offering diverse benefits such as anti-inflammatory, analgesic, antimicrobial, and neuroprotective effects. Its broad spectrum of action on various receptors in the body makes it a versatile supplement with a wide therapeutic index, ensuring high safety levels and minimal contraindications.
Comparison with CBD and Considerations for Use
PEA emerges as a reliable alternative to CBD, providing consistent efficacy with less regulatory uncertainty. While CBD shows effectiveness in treating inflammatory and pain conditions, its legal complexities pose challenges. In contrast, PEA offers a safer and more stable option for therapeutic use due to its endogenous nature and clear regulatory status. The broad body of evidence supports PEA's utility across various conditions, making it a favorable choice for practitioners.
Dosage and Complementary Nutrients for Optimal Use
For optimal use of PEA, dosages typically range from 150 to 600 milligrams daily, with the potential for higher doses based on individual needs and condition severity. When considering supplementing with PEA, practitioners may also explore complementary nutrients like polyphenols and prebiotic fibers to enhance the anti-inflammatory effects and address dysbiosis-related pain drivers. This holistic approach can offer a comprehensive strategy for managing inflammation and promoting overall well-being.
Paul Clayton is joined by fx Medicine ambassador Dr. Adrian Lopresti, who together deep dive into the role of PEA in all conditions (beyond pain), and where PEA can relieve symptoms and support resolution.
Paul is an advocate of lifestyle and nutrition in the prevention and management of disease. As a pharmaconutritionist, Paul understands the vital importance of how nutrition impacts chronic disease, and the role that chronic inflammation plays in driving ageing, as well as the onset and development neuroinflammatory and neurodegenerative disease.
Together Dr. Lopresti and Dr. Clayton examine the role of PEA in the treatment of inflammatory disease states, dosage and supplementing, and its use in the effective management of both acute and chronic conditions.
Find today's transcript and show notes here: https://www.fxmedicine.com.au/podcast/pea-perspectives-pharmaconutritionist-dr-adrian-lopresti-and-dr-paul-clayton
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***DISCLAIMER: The information provided on fx Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.***
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