The Effect of Timing Protein Intake for Muscle Hypertrophy in Mice

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Healthy Eating & Eating Disorders - Anorexia, Bulimia, Binging

Huberman Lab

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The Effect of Timing Protein Intake for Muscle Hypertrophy in Mice

The study examined whether emphasizing protein intake earlier in the day or later was better for muscle hypertrophy and strength parameters like grip strength, in mice during their active circadian cycle./nThe study included protein intake with branch chain amino acids like lucine, which are important for muscle protein synthesis./nThe mice in the study underwent resistance training with overload on one limb to produce hypertrophy, as they do not have access to the same weight training as humans.

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In this episode, I discuss what drives hunger and satiety, and the role our brain, stomach, fat and hormones play in regulating hunger and turning off the desire to eat more. I also address how protein is assimilated better early in the day than it is later in the day, and why those using intermittent fasting might want to shift their feeding window to earlier in the day.

Then I delve into the topic of disorders of eating: Anorexia Nervosa, where people starve themselves and Bulimia Nervosa where people binge and purge their food. I discuss some common myths about Anorexia such as the role of media images increasing the rates of anorexia and the myth of the "perfectionist" anorexic. I also review the symptoms, and the brain and chemical systems disrupted in this condition. I explain how anorexics become hyperaware of the fat content of foods and develop reflexive habits of fat-hyperawareness. Then I discuss the most effective treatments ranging from family-based models to those that target the habitual nature of low-fat/calorie food choices. I also discuss new more experimental clinical trials on MDMA, Psilocybin and Ibogaine for Anorexia, and both their promise and risks

I review the latest work on binge eating disorder and brain stimulation, drug treatments and thyroid disruption in Bulimia and why the treatments for Bulimia are so similar to those for ADHD. Finally, I discuss "cheat days," body dysmorphia and the growing list of novel forms of eating disorders start to finish. As always, science and science-based tools are discussed.

Read the full show notes for this episode at hubermanlab.com.