The inter-mid-singulate cortex is modifiable by experience through engagement in challenging activities throughout life. Lack of challenging activities can lead to a decrease in activation in this cortex. Super-agers, individuals who age slowly, show hyperactivity in this cortex due to regular engagement in challenging tasks, which is connected to their maintained cognitive function and longevity. This regular engagement in varied challenges is more beneficial for brain health than focusing on one specific activity, implying a strong link between the inter-mid-singulate cortex and the will to live, which is being studied in terminal cancer cases. People who psychologically fight cancer tend to live longer, suggesting a complex interplay between mental resilience, brain activity, and overall health.