Weight-Independent Benefits of Nutrient-Stimulated Hormone-Based Medications

The focus in obesity treatment has shifted from weight loss to improving overall health using medications that provide weight-independent benefits. For instance, a trial using samaglutide 2.4 milligrams showed a 20% reduction in major adverse cardiac events in individuals with obesity or overweight without diabetes, leading to the FDA expanding the medication's indication to those with pre-existing cardiovascular disease, without BMI restrictions.