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Genetic Predisposition and APO-B as Risk Factors for Cardiovascular Disease
Genetic predisposition plays a critical role in cardiovascular disease risk, as non-pharmaceutical interventions may not be effective in ameliorating it. A suboptimal APO-B level combined with the presence of LP little L allele or genetic predisposition heightens the risk of cardiovascular disease. For individuals at high risk of cardiovascular disease, the target APO-B level is under 50 milligrams per deciliter, particularly for those with a history of cardiovascular disease, hypertension, smoking, type 2 diabetes, or the LPA gene mutation.