Healing Trauma, Depression, and Your Brain with Psychedelics
The Dr. Hyman Show
The Link Between Psilocybin and Antidepressants: A Molecular Perspective
The key insight is that both psilocybin and FDA-approved antidepressants bind to the 5-He2a receptor and the track B receptor, respectively. While traditional antidepressants stimulate neurogenesis in the hippocampus, psilocybin has been found to bind a thousand times more strongly to the track B receptor. This new discovery has led to a shift in skepticism towards the effectiveness of microdosing psilocybin, with the potential for even microdoses to have a significant impact on brain health through the activation of brain-derived neurotrophic factors.
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