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Dr. Peter Attia: Supplements for Longevity & Their Efficacy
Huberman Lab
The Role of NAD and NADH in Energy Transfer
NADH functions as a crucial electron carrier in the process of energy transfer within the body. It facilitates the conversion of chemical energy from organic food sources, primarily fats and carbohydrates, into usable energy. The breakdown of these macromolecules generates smaller molecules like glucose and free fatty acids, which are further metabolized in the mitochondria. In this cellular powerhouse, the electron transport chain operates across the inner and outer mitochondrial membranes, utilizing NAD and NADH to create an electron gradient. This process ultimately leads to the synthesis of ATP, the primary energy currency, from chemical energy stored in food. The final byproducts of this energy transformation are water and carbon dioxide, which are excreted by the body. Throughout this cycle, NAD and NADH play indispensable roles in converting chemical energy to an electrical form and back, illustrating their fundamental importance to life and respiration.
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