
#133 – Manolis Kellis: Biology of Disease
Lex Fridman Podcast
The Role of irXtN and irX5 in Thermogenesis and Fat Generation
Thermogenesis is a process that regulates heat and calories in the body, controlled by irXtN and irX5. Some people are unable to turn on thermogenesis due to genetic mutations, which can be a benefit in a food-scarce environment but leads to obesity in a food-abundant one. Mitochondria and lipids play a role in this process.
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