#24 - Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and more
The Peter Attia Drive
Measure the Oxidation, Not Just the Levels
Assessing a pro-oxidative state can be accomplished through nutritional approaches or pharmacological interventions if necessary. Understanding the measurement of oxidized low-density lipoprotein (LDL) is crucial, as true oxidized LDL is formed within the arterial wall and is characterized by oxidized phospholipids. These oxidized components are the only particles that macrophages can internalize, leading to cholesterol accumulation and foam cell development, which contributes to disease. However, it is important to note that true oxidized LDL cannot be measured in plasma due to the presence of natural antioxidants. Instead, what can be detected in plasma is minimally oxidized LDL, which reveals some oxidation noted in specific structural proteins associated with the apolipoprotein B segment.
