The Peter Attia Drive
#24 - Tom Dayspring, M.D., FACP, FNLA – Part V of V: Lp(a), inflammation, oxLDL, remnants, and more
Episode guests
Podcast summary created with Snipd AI
Quick takeaways
- Lp(a) plays a crucial role in cardiovascular risks and requires more attention.
- Understanding the complexities of statins' impact on lipid levels is essential for effective treatment.
- ADMA influences endothelial function and its connection to cardiovascular health is significant.
- Omega-3 fatty acids like DHA can lower APO C Three levels and improve cardiovascular wellness.
- Triglyceride-rich lipoproteins contribute to vascular pathologies, requiring targeted therapeutic interventions.
- Apo C Three delays lipoprotein clearance, impacting atherogenic particle formation and cardiovascular risk.
Deep dives
Understanding Lipitology through Advanced Concepts
The podcast delves into intricate details of lipitology, examining diverse topics like lp little a, apo proteins, and bio markers like l p p l a two and a d m a. The discussion sheds light on the significance of lp little a in identifying cardiovascular risks and the challenges around its measurement and implications for vascular health.
Effects of Statins on Reducing lp Little a
Exploring the impact of statins on lp little a levels, the podcast emphasizes the complexities around lowering lp little a and the mechanisms involved in its clearance. The discussion highlights the difference between statins' effect on lp little a and the importance of understanding the clearance pathways to address this issue effectively.
Role of a d m a in Endothelial Function
The podcast analyzes the role of a d m a in endothelial function and nitric oxide synthesis, emphasizing its connection to impaired endothelial function and implications for cardiovascular health. The discussion navigates through the impact of a d m a on nitric oxide production and the implications for vascular reactivity and thrombotic potential.
Navigating Omega-3 Fatty Acids and Lipid Metabolism
The episode delves into the complexities of omega-3 fatty acids in lipid metabolism, focusing on the interplay between e p a and d h a in influencing ap o c three and remnants in lipid particles. The conversation touches on the significance of d h a in lowering ap o c three levels and its potential impact on cardiovascular health and longevity.
Understanding Triglyceride-Rich Lipoproteins and Atherogenesis
The podcast discusses the intricacies of triglyceride-rich lipoproteins in atherogenesis, exploring the role of vldls and remnants in delivering cholesterol to arterial walls and contributing to vascular pathologies. The dialogue navigates through the challenges of identifying and targeting remnants for therapeutic interventions and the implications for cardiovascular risk management.
Significance of Apo C Three in Lipid Metabolism
The episode highlights the significance of apo c three in lipid metabolism, emphasizing its role in delaying the clearance of lipoproteins and increasing their half-lives. The conversation delves into the impact of apo c three on lipid enrichment and its implications for atherogenic particle formation and cardiovascular disease risk.
Implications of Omega-3 DHA and APO C Three Levels
Examining the implications of omega-3 DHA in relation to APO C Three levels, the podcast explores the impact of DHA on lowering APO C Three and its potential influence on vascular health. The discussion underscores the importance of maintaining adequate DHA levels for cardiovascular wellness and longevity.
Potential Therapeutic Strategies for Reducing APO C Three
Navigating potential therapeutic strategies for reducing APO C Three, the podcast discusses the role of pharmacological agents and nutritional interventions in addressing elevated APO C Three levels. The dialogue highlights the significance of targeting APO C Three to improve lipid metabolism and mitigate cardiovascular risks.
Exploring the Relationship Between Omega-3 and Cardiovascular Health
The episode delves into the relationship between omega-3 fatty acids and cardiovascular health, exploring the impact of e p a and d h a on lipid metabolism and APO C Three levels. The conversation sheds light on the potential benefits of omega-3 supplementation in optimizing lipid profiles and reducing cardiovascular risk factors.
Influence of Omega-3 Fatty Acids on VLDL Particles
The podcast examines the influence of omega-3 fatty acids on VLDL particles, emphasizing the role of DHA in addressing APO C Three levels and enhancing lipid metabolism. The discussion underscores the importance of understanding the impact of omega-3 supplementation on VLDL composition and cardiovascular health.
Optimizing Lipid Profiles with Omega-3 Supplementation
The episode discusses strategies for optimizing lipid profiles with omega-3 supplementation, focusing on the benefits of DHA in enhancing cardiovascular health outcomes and reducing APO C Three levels. The conversation navigates through the complexities of omega-3 fatty acids in lipid metabolism and their potential impact on vascular wellness.
Omega-3 Fatty Acids in Supplements
The podcast delves into the complexity of omega-3 fatty acids in supplements, highlighting the differences between sterified and free fatty acids. It emphasizes the challenges in determining the composition of supplements and the implications for achieving optimal omega-3 levels. The discussion points out the significance of understanding the intricacies of supplement vehicles in order to effectively deliver omega-3 fatty acids for health benefits.
EPA and Omega-3 Fatty Acids in Statin Therapy
The episode explores the potential benefits of adding eicosapentaenoic acid (EPA) to statin therapy for cardiovascular health. It discusses a trial involving statins combined with EPA and the potential positive outcomes anticipated. The conversation underscores the importance of exploring innovative combinations of treatments to address cardiovascular risk factors and enhance patient care.
In this five-part series, Thomas Dayspring, M.D., FACP, FNLA, a world-renowned expert in lipidology, and one of Peter's most important clinical mentors, shares his wealth of knowledge on the subject of lipids. In Part V, Peter and Tom talk about inflammation, endothelial health, and oxidative stress as they pertain to cardiovascular disease, and our attempts to monitor them using biomarkers. They also discuss a couple of very important risk factors that too few people (and doctors) know about. Tom closes the five-part series with a tragic story about his good friend that is likely all-too-common for many practicing physicians, that both haunts and motivates Dr. Dayspring to learn as much as he can about the number one killer in the United States.
We discuss:
- Lp(a) [2:30];
- Inflammation [17:15];
- Oxidative stress markers: Lp-PLA2 and oxLDL [20:45];
- Endothelial health markers: ADMA and SDMA [34:30];
- Remnants [43:45];
- Omega-3 fatty acids (EPA and DHA) and apoC-III [55:30];
- Red blood cells and cholesterol transport [1:07:45];
- Tom's friend Earl [1:10:00];
- Peter's friend JP [1:18:15]; and
- More.
Learn more at www.PeterAttiaMD.com
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