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#347: Why Nitric Oxide is the Key to Heart and Brain Health | Dr. Nathan Bryan

The Neuro Experience

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Understanding Enzymology and Biochemistry for Nitric Oxide Production

The enzymology and biochemistry behind nitric oxide production involve a complex reaction where an enzyme converts L-arginine into nitric oxide gas and citrulline. The rate-limiting step is the oxidation of a critical cofactor called BH4, as its oxidation leads the enzyme to produce superoxide instead of nitric oxide. Preventing BH4 oxidation is crucial to maintain normal nitric oxide production and prevent age-related diseases like cardiovascular issues, Alzheimer's, and diabetes by regulating plaque deposition and maintaining normal coronary flow through nitric oxide production by endothelial cells.

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