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Dr. David Sinclair: The Biology of Slowing & Reversing Aging

Huberman Lab

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Longevity Pathways Interaction and Benefits

Longevity pathways, such as sirtuins and mTOR, interact with each other based on the nutrients you consume. Sirtuins respond to sugar and insulin, while mTOR senses protein and amino acids intake. When fasting, sirtuin activation increases while mTOR downregulates, leading to several benefits like boosting the body's defenses, improving insulin sensitivity, increasing energy levels, and cell repair. This interaction between sirtuins and mTOR is crucial for longevity.

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