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#283 ‒ Gut health & the microbiome: improving and maintaining the microbiome, probiotics, prebiotics, innovative treatments, and more | Colleen Cutcliffe, Ph.D.

The Peter Attia Drive

NOTE

Acromancia's Stimulation of GLP1 Secretion in Gut Microbiome

Acromancia stimulates GLP1 secretion in the gut microbiome through multiple mechanisms. It secretes a protein called P9 that binds to ICAM2 receptors in L cells, stimulating the production of GLP1. Additionally, Acromancia produces propionate, which can be converted into butyrate and bind to G protein coupled receptors 42 and 44 in L cells, further stimulating GLP1 secretion. Acromancia mucinophila and Clostridium butyrichum are the only two strains shown to directly stimulate GLP1, with the latter producing butyrate. GLP1 not only helps in insulin secretion and sugar metabolism after meals, but also induces satiety by slowing GI transit and affecting neurotransmitters to reduce cravings and create a feeling of fullness.

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