Addiction leads to a cycle where the brain convinces you to give in by making you feel jittery and promising to ease negativity. If you resist, withdrawal symptoms like headaches and body pain occur as the brain gets angry and demands the substance, eventually causing intense discomfort. Giving in leads to self-blame by the brain, which makes the individual feel punished for not satisfying its cravings, similar to how the body reacts to hunger and thirst by sending negative signals.