New medications for depression are not significantly better than old medications, with around 70% of patients still experiencing major depressive disorder after the first antidepressant treatment. After 4 levels of treatment, one third of patients are still clinically depressed, and this treatment protocol is not working well as half of the participants dropped out of the study. Some researchers argue that the remission criteria were changed during the study, and the actual remission rate after 4 treatment levels could be as low as 35%. Overall, the current state of affairs for depression treatment is that many patients do not significantly improve even after multiple layers of treatment.

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