AI-powered
podcast player
Listen to all your favourite podcasts with AI-powered features
1min snip
Why we age and how to slow it | Venki Ramakrishnan
The Proof with Simon Hill
Balance Between Risks and Benefits in Genetic Traits
Aging therapeutics face challenges due to the concept of antagonistic pleiotropy, where certain genetic traits can present both advantages and disadvantages depending on environmental context. For instance, a high level of Lp(a) is linked to increased risks for thrombosis and atherosclerosis, yet historically, it may have played a crucial role in wound healing during times of higher infection and injury. Some genetic variants associated with high Lp(a) are more common in centenarians, reflecting adaptability to environmental pressures. These variants may contribute to a higher risk of cancer and infection but provide protection against Alzheimer's, underlining the necessity of considering environmental factors when evaluating genetic risks and benefits.
00:00
Transcript
Episode notes
Get the Snipd
podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered
Discover
highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any
moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share
& Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered
podcast player
Listen to all your favourite podcasts with AI-powered features
Discover
highlights
Listen to the best highlights from the podcasts you love and dive into the full episode