Suppressing mTOR, which can lead to muscle growth, poses a dilemma for individuals over 50 who are prone to muscle wasting. While mTOR simulates fasting and its suppression might lead to being very thin, research on the effects of rapamycin, which suppresses mTOR, on sarcopenia is still inconclusive. Despite evidence suggesting rapamycin does not increase muscle loss, the issue remains controversial and should not be disregarded.

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