Regenerative Health with Max Gulhane, MD cover image

36. Jalal Khan: Circadian Biology, Mitochondria, POMC and Why You Need Sunlight for Optimal Health

Regenerative Health with Max Gulhane, MD

NOTE

Controlled Signaling Prevents Protein Misfolding

Signaling from the mitochondria to the nucleus is crucial in determining protein expression in the cell. Controlled signaling ensures that the nucleus reacts appropriately and expresses proteins accordingly. However, excessive signaling from the mitochondria can lead to errors in reading nuclear DNA, causing the cell to produce proteins with different structures and functions. This phenomenon can result in the development of various chronic diseases, neurodegenerative diseases, and metabolic disorders that cannot be solely attributed to nuclear genes.

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