Exploring the Role of Polyphenols in Modulating Gene Expression with Age

As we age, genes that protect us from disease are turned off while disease-driving genes are activated. Polyphenols, known as methylation adaptogens or epineutrients, have shown the ability to turn on tumor suppressor genes that are usually inhibited in many cancer types. Nutrients like resveratrol, curcumin, genistein, luteolin, sulforaphane, and EGCG can reverse the hypermethylated status of tumor suppressor genes. Polyphenols influence gene expression, acting as anti-cancer, anti-inflammatory, and antioxidant agents. It is essential to incorporate polyphenols along with methyl donors through food sources to optimize gene expression for healthy aging. Studies have indicated that a daily intake of around 3,000 milligrams of polyphenols can positively impact DNA methylation patterns, with further research ongoing to explore its broader effects on gene expression.