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Everything you need to know about metabolic health | Metabolic Health Masterclass

The Proof with Simon Hill

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Tiny Surpluses, Big Consequences

A small, sustained calorie surplus can lead to muscle insulin resistance, resulting in elevated blood glucose levels. Consequently, rather than storing excess glucose as glycogen, the body converts it into fat through de novo lipogenesis in the liver. This accumulation of liver fat triggers insulin resistance, impairing the liver's ability to regulate blood glucose. The pancreas responds to rising blood glucose by increasing insulin production, which subsequently further boosts fat synthesis in the liver. The fat produced is packaged into atherogenic lipoproteins, specifically very low-density lipoproteins (VLDL), which are released into circulation, posing cardiovascular risks.

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