Macrophages and Atherosclerosis

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Macrophages are vital immune cells present in the sub-entimal space that work to clear away debris, including oxidized LDL particles trapped in proteoglycans. In atherosclerosis, macrophages act as emergency workers by consuming debris such as necrotic macrophages. The present lipid hypothesis suggests that when macrophages encounter oxidized LDL particles, they consume them but get stuck, contributing to the progression of atherosclerosis.

Today, Paul has Dave Feldman on the podcast to discuss, in depth, a recent study that he conducted about LDL and cardiovascular risk and what this may mean for the future of medicine.

*Produced by Mountain Valley Media

00:03:30 The genesis of Dave’s most recent study

00:07:00 is FH a phenotype or genotype polygenetic vs monogenetic

00:22:30 Dave’s overall perspective while conducting studies

0:24:00 Diving into Dave Feldman’s most recent study: Does APOE-B cause atherosclerosis

00:42:30 How the medical community has received this study

00:46:30 Do credentials matter?

00:58:30 Thoughts on Statins

01:04:45 What alters lipid levels

01:13:30 Connect with Dave

References:

Twitter: @realdavefeldman